How Is Stiff Person Syndrome Treated?

Treatment of stiff person syndrome (SPS) focuses on the specific symptoms present in each person.

Benzodiazepines, diazepam, or baclofen may be used to treat muscle stiffness and spasms.

Anti-seizure medications and pain medications may also be effective for some people.23 Jul 2017

Is Stiff person syndrome fatal?

The management of stiff person syndrome is difficult and although success has been reported with the use of plasmapheresis, immunoglobulin, and some cytotoxic agents, most patients continue to follow a relentless and ultimately fatal course.

Can stiff person syndrome be cured?

Treatment with IVIg, anti-anxiety drugs, muscle relaxants, anti-convulsants, and pain relievers will improve the symptoms of SPS, but will not cure the disorder. Most individuals with SPS have frequent falls and because they lack the normal defensive reflexes; injuries can be severe.

Is Stiff person syndrome progressive?

Stiff person syndrome (SPS) is a rare, progressive syndrome that affects the nervous system, specifically the brain and spinal cord. Symptoms may include extreme muscle stiffness, rigidity and painful spasms in the trunk and limbs, severely impairing mobility. Spasms can generate enough force to fracture bone.

What is stiff muscle syndrome?

Stiff-person syndrome (SPS) is a rare neurological disorder with features of an autoimmune disease. SPS is characterized by fluctuating muscle rigidity in the trunk and limbs and a heightened sensitivity to stimuli such as noise, touch, and emotional distress, which can set off muscle spasms.27 Mar 2019